An autoimmune disease is this special sort of disease where your own immune cells have gone rogue and start to attack your own cells right.
Hepatitis happens to mean inflammation of the liver so it's reasonable to say that autoimmune hepatitis is this resulting inflammation of your liver tissue because they're being attacked by your own immune cells.
Like many autoimmune diseases the root cause of autoimmune hepatitis is ultimately not super clear.
Some researchers think it's a combination of environmental triggers and genetic predisposition, it tends to occur most often in young women and the female to male ratio is about four to one.
Also though an important piece of the genetic puzzle is the human leukocyte antigen system shortened to HLA which is this location of genes on chromosome six that regulate our immune functions.
Specifically these genes control the proteins that are encoded and used on the cells surface to present foreign molecules to the immune system.
Although they present antigens they're also a form of antigen themselves they aren't though the same type of antigen as one on an infectious molecule but actually a low antigens that vary from person to person and are actually specific self proteins.
How Hepatitis A and Hepatitis B Affect Liver?
If you have hepatitis A or B your liver is inflamed because you have been infected with either the hepatitis A virus or the hepatitis B virus.
Your liver is a soft flexible organ that performs many important functions. The functional parts of your liver are called hepatic lobules your hepatic lobules filter all of the blood in your body.
As the blood passes through your hepatic lobules breakdown harmful substances, remove bacteria and worn out blood cells, and forms clotting factors that control bleeding.
After a meal your liver stores nutrients to provide your body with energy when needed. your liver also makes a substance called bile.
Your gallbladder stores bile and releases it into your small intestine to help digest fats in the food you eat.
If you have hepatitis A the virus entered your body when you were exposed to fecal matter from a person infected with the virus.
You may have been exposed to the virus by eating contaminated food or water contact with infected feces such as during a diaper change or having unprotected sex with a person infected with the virus.
If you have hepatitis B the virus entered your body when you are exposed to the blood or other body fluids from a person infected with the virus.
This could have happened from sharing a drug syringe with an infected person.
Other ways you may have been exposed to the virus include having sex with someone infected by the virus sharing personal hygiene items such as razors or toothbrushes used by an infected person.
Direct contact with the blood or body fluids of an infected person or when a mother passes it to her baby during birth.
When either the hepatitis or be virus enters your liver it invades your liver cells, and makes copies of itself.
In response your body sends immune cells to attack both the virus and liver cells infected with the virus. as a result these liver cells become inflamed and then die.
Over time scar tissue forms around dead and infected liver cells, which prevents your liver from working properly.
If you have a chronic hepatitis B infection your liver contains a large amount of scar tissue called cirrhosis, which limits blood flow and result in permanent shrinking and hardening of your liver.
If you have hepatitis A your doctor won't prescribe any medical treatment because your immune cells will eventually find and destroy all of the hepatitis A viruses in your body.
If you have hepatitis B your immune system will usually remove all the hepatitis B viruses from your body.
In some people with chronic hepatitis B particularly children their immune cells are unable to remove all of the hepatitis B viruses.
If you have chronic hepatitis B and your immune system can't get rid of the virus completely, your doctor may prescribe antiviral medication.
If you have a severe case of chronic hepatitis B your doctor may recommend a liver transplant operation.